A rare case of malignant epithelioid angiomyolipoma in multiple locations: multifocal disease or metastases?

نویسندگان

  • Daniele Crocetti
  • Giuseppe Pedullà
  • Maria Rita Tarallo
  • Antonietta De Gori
  • Annalisa Paliotta
  • Giuseppe Cavallaro
  • Giorgio De Toma
چکیده

BACKGROUND Perivascular epithelioid cell tumors (PEComas), make up a family of extremely rare mesenchymal neoplasms, with characteristic morphological, immunohistochemical and molecular findings. Malignant PEComas and gastrointestinal epithelioid angiomyolipoma (E-AML) are especially rare. To the best of our knowledge E-AML have not been found in the breast. The difficulty in determining what constitutes optimal therapy for PEComas, owing to the sparse literature available, led us to report this rare case. METHODS We report a case of a 44-year-old woman, with a family history of multiple endocrine neoplasia syndrome (MEN) (gastrinoma, medullary thyroid cancer and parathyroid hyperplasia), affected by PEComa located in the kidney, stomach, ileum, liver and breast. RESULTS The renal, gastric, ileal and mammarian tumors were completely resected, with no evidence of local disease. Liver lesions were biopsied. The morphological and immunohistochemical findings confirm the diagnosis of PEComa. CONCLUSION On this basis it is difficult to determine if some E-AML are multifocal tumors or metastatic disease.

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عنوان ژورنال:
  • Annali italiani di chirurgia

دوره 85 2  شماره 

صفحات  -

تاریخ انتشار 2014